Publications

UCL
Dufrane D., Gianello
P. 2008. Pig islet xenotransplantation into a nonhuman primate model [Overview]. Transplantation, 86(6):753-760.
Goto M., Tjernberg J., Dufrane D., et al. 2008. Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation, 15:225-234.
Dufrane D., Maillart J.F.,Aouassar N.,Goebbels R.M.,Guiot Y.,Gianello P. 2009. Native pancreatic α-cell adaptation in Streptozotocin-induced diabetic primates: importance for pig islet xenotransplantation. Xenotransplantation, 16(3):152-163.
Dufrane D., Gianello P. 2009. Pig islets for clinical islet xenotransplantation [Review]. Current Opinion in Nephrology and Hypertension, 18(6):495-500.
Vériter S., Mergen J.,Goebbels R.M., Aouassar N., Grégoire C., Jordan B., Levêque P., Gallez B., Gianello P., Dufrane D. 2010. In Vivo selection of biocompatible alginates for islet encapsulation and subcutaneous transplantation. Tissue Engineering Part A, 16(5):1503-1513. Dufrane D., R.M. Goebbels, Gianello P. 2010. Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates Up to 6 months Without Immunosuppression. Transplantation, 90 (10):1054-1062.
Igarashi Y., D’hoore W., Goebbels R.M., Gianello P., Dufrane D. 2010. Beta-5 Score to evaluate pig islet graft function in a primate preclinical model. Xenotransplantation, 17(6):449-459.
Veriter S., Aouassar N., Adnet P.Y., Paridaens M.S., Stuckman C., Jordan B., Karroum O., Gallez B., Gianello P., Dufrane D. 2011.The impact of hyperglycemia and the presence of encapsulated islets on oxygenation within a bioartificial pancreas in the presence of mesenchymal stem cells in a diabetic wistar rat model. Biomaterials, 32(26):5945-5946.
Dufrane D., Gianello P. 2011. Pig islet for xenotransplantation in humans: Structural and physiological compatibility for human clinical application. Transplantation Reviews2012 Jul;26(3):183-8.
Vériter S, Aouassar N, Beaurin G, Goebbels RM, Gianello P, Dufrane D. Improvement of Pig Islet Function by In Vivo Pancreatic Tissue Remodeling: A "Human-Like" Pig Islet Structure With Streptozotocin Treatment. Cell Transplant. 2012 Oct 8.
Vériter S, Gianello P, Assouar N, Beaurin G, Dufrane D. Improvement of subcutaneous bioartificial pancreas vascularization and function by co- encapsulation of pig islets and mesenchymal stem cells in primates Cell Transplantation, 2013 in press.

 

GCU
Groenen MA, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y, Rothschild MF,
et al. Analyses of pig genomes provide insight into porcine demography and evolution. Nature. 2012 Nov 15;491(7424):393-8.
Claire Crossan PJB, John Craft, Yasu Takeuchi, Harry R Dalton and Linda Scobie. Identification of Hepatitis E virus Genotype-3 in shellfish in the United Kingdom. Emerg Infect Dis. 2012;18(12).
Harrison A, Scobie L, Crossan C, Parry R, Johnston P, Stratton J, et al. Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in Southwest England: A case-control study. J Med Virol. 2012 Nov 20.
Fishman JA, Scobie L, Takeuchi Y. Xenotransplantation-associated infectious risk: a WHO consultation. Xenotransplantation. 2012 Mar- Apr;19(2):72-81.
Stacey Busby, Susan Lang, Yasu Takeuchi1, Pavel Vesely, Bjoern Petersen, Cesare Galli and Linda Scobie. Antibiotic susceptibility and resistance of Staphylococcus aureus isolated from porcine skin xenografts: risk to recipients with thermal injury. 2012 In revision for Transplantation.
Le Bas-Bernardet, Tillou X, Poirier N, Dilek N, Chatelais M, Julie Devallière, Charreau B, Minault D, Hervouet J, Renaudin K, Crossan C, Scobie L, Cowan PJ, d’Apice AJF, Galli C, Cozzi E, Soulillou JP, Vanhove B and Blancho G.Xenotransplantation of Galactosyl-transferase knock-out, CD55, CD59 CD39 and fucosyl transeerase transgenic pig kidneys into baboons. Transplant Proc. 2011 Nov;43(9):3426-30 Detection of porcine endogenous retrovirus (PERV) viremia in diseased versus healthy U.S. pigs by quantitative real-time RT-PCR.
Narinder P, RR. Baker, S Schalk, L Scobie, A W. Tucker, T Opriessnig; Transbound Emerg Dis. Transbound Emerg Dis. 2011 Aug;58(4):344-51. doi: 10.1111/j.1865-1682.2011.01210.x. Epub 2011 Mar 13. Microbial Safety in Xenotransplantation.
Mueller NJ, Takeuchi Y, Mattiuzzo G, Scobie L.Curr Opin Organ Transplant. 2011 Apr;16(2):201-6.
Mattiuzzo G, Takeuchi Y and Scobie L. Xenotransplantation: Methods and Protocols. (2010) Methods in Molecular Biology, Humana Press.
Scobie L.Porcine pathogens and xenotransplantation: PERV and beyond! Xenotransplantation (2010): 17: 94–120
Bakri M, Sutherland A, Brown D, Crossan C, Vesely P and Scobie L. Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts. (2009) Xenotransplantation Nov;16(6):472-6.

 

AVT
Brunetti D, Perota A, Lagutina I, Colleoni S, Duchi R, Calabrese F, Seveso M, Cozzi E, Lazzari G, Lucchini F, Galli C
, 2008: Transgene expression of green fluorescent protein and germ line transmission in cloned pigs derived from in vitro transfected adult fibroblasts. Cloning and stem cells 10, 409-419.
Galli C, Lagutina I, Crotti G, Colleoni S, Turini P, Ponderato N, Duchi R, Lazzari G, 2003: Pregnancy: a cloned horse born to its dam twin. Nature 424, 635.
Galli C, Perota A, Brunetti D, Lagutina I, Lazzari G, Lucchini F, 2010: Genetic engineering including superseding microinjection: new ways to make GM pigs. Xenotransplantation 17, 397-410.
Lagutina I, Lazzari G, Galli C, 2006: Birth of cloned pigs from zona-free nuclear transfer blastocysts developed in vitro before transfer. Cloning and stem cells 8, 283-293.
Lombardo A, Genovese P, Beausejour CM, Colleoni S, Lee YL, Kim KA, Ando D, Urnov FD, Galli C, Gregory PD, Holmes MC, Naldini L, 2008: Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nature biotechnology 25, 1298-1306.

 

BIOT
Muenthaisong, S., O. Ujhelly, Z. Polgar, E. Varga, Z. Ivics, M. Pirity, and A. Dinnyes,
Generation of mouse induced pluripotent stem cells from different genetic backgrounds using Sleeping Beauty transposon mediated gene transfer. Experimental Cell Research, 2012. 318: p. 2482-2489. Hall, V.J., M. Kristensen, M.A. Rasmussen, O. Ujhelly, A. Dinnyes, and P. Hyttel, Temporal repression of endogenous pluripotency genes during reprogramming of porcine induced pluripotent stem cells. Cellular Reprogramming, 2012. 14(3): p. 204-216.
Wilmut, I., N. Beaujean, P.A. de Sousa, A. Dinnyes, T.J. King, L.A. Paterson, D.N. Wells, and L.E. Young, Somatic cell nuclear transfer. Nature, 2002. 419(6907): p. 583-586.
Denning, C., S. Burl, A. Ainslie, J. Bracken, A. Dinnyes, J. Fletcher, T. King, M. Ritchie, W.A. Ritchie, M. Rollo, P. de Sousa, A. Travers, I. Wilmut, and A.J. Clark, Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep. Nature Biotechnology, 2001. 19(6): p. 559-562.
De Sousa, P.A., J.R. Dobrinsky, J. Zhu, A.L. Archibald, A. Ainslie, W. Bosma, J. Bowering, J. Bracken, P.M. Ferrier, J. Fletcher, B. Gasparrini, L. Harkness, P. Johnston, M. Ritchie, W.A. Ritchie, A. Travers, D. Albertini, A. Dinnyes, T.J. King, and I. Wilmut, Somatic cell nuclear transfer in the pig: Control of pronuclear formation and integration with improved methods for activation and maintenance of pregnancy. Biology of Reproduction, 2002. 66(3): p. 642-65

 

AVD
Fabian G, Farago N, Feher LZ, Nagy LI, Kulin S, Kitajka K, Bito T, Tubak V, Katona RL, Tiszlavicz L, Puskas LG. High-Density Real-Time PCR-Based in Vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity. Int J Mol Sci. 2011;12(9):6116-34.
Vass L, Kelemen JZ, Fehér LZ, Lorincz Z, Kulin S, Cseh S, Dormán G, Puskás LG. Toxicogenomics screening of small molecules using high-density, nanocapillary real-time PCR. Int J Mol Med. 2009 Jan;23(1):65-74.
Inui M, Suda M, Okino S, Nonaka H, Puskás LG, Vertès AA, Yukawa H. Transcriptional profiling of Corynebacterium glutamicum metabolism during organic acid production under oxygen deprivation conditions. Microbiology. 2007 Aug;153(Pt 8):2491-504.
Kelemen JZ, Kertész-Farkas A, Kocsor A, Puskás LG. Kalman filtering for disease-state estimation from microarray data. Bioinformatics. 2006 Dec 15;22(24):3047-53.
Nagy ZB, Kelemen JZ, Fehér LZ, Zvara A, Juhász K, Puskás LG. Real-time polymerase chain reaction-based exponential sample amplification for microarray gene expression profiling. Anal Biochem. 2005 Feb 1;337(1):76-83.

This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 601827